The Aghi Lab

The Manish K. Aghi Lab at the University of California, San Francisco

The Helen Diller Family Cancer Research Building

1450 3rd Street

Room HD-410

San Francisco, CA 94158


Copyright © 2013 The Aghi Lab.

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The People


Arman Jahangiri, B.S., M.D. Ph.D. candidate


Howard Hughes Medical Institute, Fellow

Medical Student, Graduate Student

 

Arman Jahangiri has completed the first three years of medical school at UT Southwestern where he served as co-president of the class of 2012. He is currently in the midst of a research fellowship as a HHMI fellow in the Aghi lab.  Arman is devoting his basic-science focus to studying angiogenesis, while further characterizing the extracellular matrix response to bevacizumab treatment in human glioblastoma.  He is also avidly involved in clinical research with much curiosity for pituitary disorders as well as the benefit of minimally invasive procedures. With the basic-science and clinical experiences gained from the Aghi lab and Dr. Aghi’s close mentorship, Arman hopes to pursue a career in neurosurgery with the ultimate goal of  becoming a physician-scientist devoting his life to the ultimate cumulative effort of finding a cure for  glioblastoma.

Education, Training, and Previous Positions

2008: BS, University of Houston

2008-2012: MD, candidate, University of Texas, Southwestern Medical Center

2011-2012: Research Fellowship, Howard Hughes Medical Institute, UCSF Brain Tumor Research Center.

2012-2013: Advanced Fellowship, Howard Hughes Medical Institute, UCSF Brain Tumor Research Center.


Selected Professional Memberships and Appointments

American Association of Neurological Surgeons (AANS)

Congress of Neurological Surgeons (CNS)


Selected Honors and Awards

2013: Phi Kappa Phi, Love of Learning Scholarship

2013: Integra Foundation Award, Congress of Neurological Surgeons (CNS)


Selected Recent Publications

Jahangiri A, Carbonell WS, Aghi MK. Beta1 integrin: critical path to antiangiogenic therapy resistance. Cancer Research, In Press.


Jahangiri A, Weiss WA. It takes two to tango: dual inhibition of PI3K & MAPK in rhabdomyosarcoma. Clin Cancer Res. 2013 Oct 4.


Jahangiri A, Potts M, Kunwar S, Blevins L, El-Sayed IH, Aghi MK. Extended endoscopic endonasal approach for suprasellar Rathke's cleft cysts. Journal of Clinical Neuroscience, In Press.


Jahangiri A, Wagner J, Tran MT, Miller LM, Tom MW, Kunwar S, Blevins L Jr, Aghi MK. Factors predicting postoperative hyponatremia and efficacy of hyponatremia management strategies after more than 1000 pituitary operations [published online ahead of print August 23, 2013]. J Neurosurg. doi:10.3171/2013.7.JNS13273


Jahangiri A, Clark AJ, Han SJ, Kunwar S, Blevins LS Jr, Aghi MK. Socioeconomic factors associated with pituitary apoplexy [published online ahead of print July 26, 2013]. J Neurosurg. doi: 10.3171/2013.6.JNS122323


Jahangiri A, Wagner JR, Pekmezci M, Hiniker A, Chang EF, Kunwar S, Blevins L, Aghi MK. A Comprehensive Long-Term Retrospective Analysis of Silent Corticotrophic Adenomas versus Hormone-Negative Adenomas. Neurosurgery. 2013 Mar 5. [Epub ahead of print] PubMed PMID: 23467251.

Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of anti-angiogenic therapy resistance. Clin Cancer Res. 2013 Jan 10. [Epub ahead of print] PubMed PMID: 23307858.

Jahangiri A, Jian B, Miller L, El-Sayed IH, Aghi MK. Skull base chordomas: clinical features, prognostic factors, and therapeutics. Neurosurg Clin N Am. 2013 Jan;24(1):79-88. Epub 2012 Oct 10. PubMed PMID: 23174359.

Ivan ME, Jahangiri A, El-Sayed IH, Aghi MK. Minimally invasive approaches to the anterior skull base. Neurosurg Clin N Am. 2013 Jan;24(1):19-37. Epub 2012 Sep 13. PubMed PMID: 23174355.

Hu YL, Jahangiri A, Delay M, Aghi MK. Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. Cancer Res. 2012 Sep 1;72(17):4294-9. Epub 2012 Aug 22. Review. PubMed PMID: 22915758

Hu YL, Jahangiri A, De Lay M, Aghi MK. Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy. Autophagy. 2012 Jun;8(6):979-81.  Epub 2012 Jun 1. PubMed PMID: 22714142

Jahangiri A, DeLay M,  Carbonell WS, Hu YL, Tsao S, Tom MW, Paquette J,Tokuyasu TA, Aghi MK. Microarray analysis verifies two distinct phenotypes of glioblastomas resistant to antiangiogenic therapy. Clin Cancer Res. 2012 May 15;18(10):2930-42. Epub 2012 Apr 3. PubMed PMID: 22472177;

Hu YL, Jahangiri A, DeLay M,  Molinaro AM, Rose SD, Carbonell WS, Aghi MK. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012 Apr 1;72(7):1773-83. Epub 2012 Mar 23. PubMed PMID: 22447568

Jahangiri A, Aghi MK. Pseudoprogression and treatment effect. Neurosurg Clin N Am. 2012 Apr;23(2):277-87, viii-ix. Epub 2012 Feb 14. Review. PubMed PMID: 22440871.

Jahangiri A, Aghi MK. Biomarkers predicting tumor response and evasion to anti-angiogenic therapy. Biochim Biophys Acta. 2012 Jan;1825(1):86-100.  Epub 2011 Oct 30. Review. PubMed PMID: 22067555.

Jahangiri A, Lamborn KR, Blevins L, Kunwar S, Aghi MK. Factors associated with delay to pituitary adenoma diagnosis in patients with visual loss. J Neurosurg. 2011 Jul 8. [Epub ahead of print]

Jahangiri A, Molinaro AM, Tarapore PE, Blevins L Jr, Auguste KI, Gupta N, Kunwar S, Aghi MK. Rathke cleft cysts in pediatric patients: presentation, surgical management, and postoperative outcomes. Neurosurg Focus. 2011 Jul;31(1):E3

Jahangiri A, Potts MB, Lamborn KR, Blevins LS, Kunwar S, Aghi MK. Suprasellar rathke cleft cysts: clinical presentation and treatment outcomes. Neurosurgery 2011;69(5):1058-69.

Jahangiri A, Tate MC,  Blevins L, Kunwar S, Aghi MK. Infected Rathke cleft cysts: distinguishing factors and factors predicting recurrence. Neurosurgery 2010;67(3):762-9.