The Aghi Lab

The Manish K. Aghi Lab at the University of California, San Francisco

The Helen Diller Family Cancer Research Building

1450 3rd Street

Room HD-410

San Francisco, CA 94158

 

Aghi Laboratory

Dr. Aghi's research interests focus on the microenvironment of glioblastoma.  Scientists in Dr. Aghi's basic science laboratory are working to

  1. (1)Characterize and exploit the role of marrow-derived immune cells in the progression of the anti-VEGF evasive glioblastomas.

  2. (2)determine how gliomas become evasive to anti-angiogenic treatments that have become increasingly used in glioblastoma treatment since the accelerated FDA approval of the anti-VEGF neutralizing antibody bevacizumab for glioblastoma treatment;

  3. (3)determine the impact of tumor mutations and cell signaling pathways in the sensitivity of human glioblastomas to anti-angiogenic treatment; and

  4. (4)determine the ability of hypoxia to upregulate autophagy as a cell survival mechanism in glioblastoma, the impact of mutations in this process, and whether autophagy might contribute to evasion to anti-angiogenic therapy.


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