The Aghi Lab
The Manish K. Aghi Lab at the University of California, San Francisco
The Helen Diller Family Cancer Research Building
1450 3rd Street
Room HD-210
San Francisco, CA 94158
Aghi Laboratory
Dr. Aghi's research interests focus on the microenvironment of glioblastoma. Scientists in Dr. Aghi's basic science laboratory are working to
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(1)Characterize and exploit the role of marrow-derived immune cells in the progression of the anti-VEGF evasive glioblastomas.
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(2)determine how gliomas become evasive to anti-angiogenic treatments that have become increasingly used in glioblastoma treatment since the accelerated FDA approval of the anti-VEGF neutralizing antibody bevacizumab for glioblastoma treatment;
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(3)determine the impact of tumor mutations and cell signaling pathways in the sensitivity of human glioblastomas to anti-angiogenic treatment; and
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(4)determine the ability of hypoxia to upregulate autophagy as a cell survival mechanism in glioblastoma, the impact of mutations in this process, and whether autophagy might contribute to evasion to anti-angiogenic therapy.
