The Aghi Lab


Jahangiri A, Carbonell WS, Aghi MK.  Beta1 Integrin: Critical Path to Antiangiogenic Therapy Resistance.  Cancer Research, in press.

Carbonell WS, De Lay M, Jahangiri A, Park C, Aghi MK.  Targeting Beta1 Integrin Potentiates Bevacizumab Therapy and Inhibits Growth of Bevacizumab-Resistant Glioblastoma Multiforme.  Cancer Research 73: 3145-3154. 2013.

Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of anti-angiogenic therapy resistance. Clin Cancer Res. 2013 Jan 10. [Epub ahead of print] PubMed PMID: 23307858.

Hu YL, Jahangiri A, Delay M, Aghi MK. Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. Cancer Res. 2012 Sep 1;72(17):4294-9. Epub 2012 Aug 22. Review. PubMed PMID: 22915758

Hu YL, Jahangiri A, De Lay M, Aghi MK. Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy. Autophagy. 2012 Jun;8(6):979-81.  Epub 2012 Jun 1. PubMed PMID: 22714142

DeLay M, Jahangiri A,   Carbonell WS, Hu YL, Tsao S, Tom MW, Paquette J,Tokuyasu TA, Aghi MK. Microarray analysis verifies two distinct phenotypes of glioblastomas resistant to antiangiogenic therapy. Clin Cancer Res. 2012 May 15;18(10):2930-42. Epub 2012 Apr 3. PubMed PMID: 22472177;

Hu YL, Jahangiri A, DeLay M,  Molinaro AM, Rose SD, Carbonell WS, Aghi MK. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012 Apr 1;72(7):1773-83. Epub 2012 Mar 23. PubMed PMID: 22447568

Jahangiri A, Aghi MK. Biomarkers predicting tumor response and evasion to anti-angiogenic therapy. Biochim Biophys Acta. 2012 Jan;1825(1):86-100.  Epub 2011 Oct 30. Review. PubMed PMID: 22067555.

Copyright © 2013 The Aghi Lab.

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The Manish K. Aghi Lab at the University of California, San Francisco

The Helen Diller Family Cancer Research Building

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Room HD-410

San Francisco, CA 94158

Carbonell et. al, May 15, 2013 Cover